Article

FMRP Links Optimal Codons to mRNA stability in Neurons

2019-10-10

Abstract excerpt

Fragile X syndrome (FXS) is caused by inactivation of the FMR1 gene and loss of encoded FMRP, an RNA binding protein that represses translation of some of its target transcripts. Here we use ribosome profiling and RNA-seq to investigate the dysregulation of translation in the mouse brain cortex. We find that most changes in ribosome occupancy on hundreds of mRNAs are largely driven by dysregulation in transcript...

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Literature Corpus work: a6d60661-135b-5b5d-abf2-3808a8ce916c
DOI: 10.1101/801449

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