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Article

A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies.

Developmental cell - 26 Jul 2021

Tiu Gerald C, Kerr Craig H, Forester Craig M, Krishnarao Pallavi S, Rosenblatt Hannah D, Raj Nitin, Lantz Travis C, Zhulyn Olena, Bowen Margot E, Shokat Leila, Attardi Laura D, Ruggero Davide, Barna Maria

Abstract excerpt

In ribosomopathies, perturbed expression of ribosome components leads to tissue-specific phenotypes. What accounts for such tissue-selective manifestations as a result of mutations in the ribosome, a ubiquitous cellular machine, has remained a mystery. Combining mouse genetics and in vivo ribosome profiling, we observe limb-patterning phenotypes in ribosomal protein (RP) haploinsufficient embryos, and we uncover...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 34242585
DOI: 10.1016/j.devcel.2021.06.013
PMCID: PMC8319123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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