Article

Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus

2023-09-13

Abstract excerpt

Although Rhinolophus bats harbor diverse clade 3 sarbecoviruses, the structural determinants of receptor tropism along with the antigenicity of their spike (S) glycoproteins remain uncharacterized. Here, we show that the African Rinolophus bat clade 3 sarbecovirus PRD-0038 S has a broad ACE2 usage and that RBD mutations further expand receptor promiscuity and enable human ACE2 utilization. We determined a cryoEM...

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Literature Corpus work: 3dff5ea6-d13b-54e3-ada1-8bdd2f7b6999
DOI: 10.1101/2023.09.12.557371

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