Article

ACE2 binding is an ancestral and evolvable trait of sarbecoviruses

2021-07-19

Abstract excerpt

Two different sarbecoviruses have caused major human outbreaks in the last two decades 1,2 . Both these sarbecoviruses, SARS-CoV-1 and SARS-CoV-2, engage ACE2 via the spike receptor-binding domain (RBD) 2–6 . However, binding to ACE2 orthologs from humans, bats, and other species has been observed only sporadically among the broader diversity of bat sarbecoviruses 7–11 . Here, we use high-throughput assays 12...

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Literature Corpus work: a25b689e-f9da-546e-96a0-36aa4d3b5ccc
DOI: 10.1101/2021.07.17.452804

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