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Article

Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus

20 Nov 2023

Abstract excerpt

Although Rhinolophus bats harbor diverse clade 3 sarbecoviruses, the structural determinants of receptor tropism along with the antigenicity of their spike (S) glycoproteins remain uncharacterized. Here, we show that the African Rhinolophus bat clade 3 sarbecovirus PRD-0038 S has a broad angiotensin-converting enzyme 2 (ACE2) usage and that receptor-binding domain (RBD) mutations further expand receptor...

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Identifiers

PMID: 37989312
DOI: 10.1016/j.chom.2023.10.018

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