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Article

Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses

7 Feb 2025

Abstract excerpt

The angiotensin-converting enzyme 2 (ACE2) receptor is shared by various coronaviruses with distinct receptor-binding domain (RBD) architectures, yet our understanding of these convergent acquisition events remains elusive. Here, we report that two bat MERS-related coronaviruses (MERSr-CoVs) infecting Pipistrellus nathusii (P.nat)-MOW15-22 and PnNL2018B-use ACE2 as their receptor, with narrow ortholog...

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Identifiers

PMID: 39922191
DOI: 10.1016/j.cell.2024.12.031

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