Article

Clade-3 Bat Sarbecovirus PRD0038 Reveals Constraints on Coronavirus Emergence and Immune Sensitivity

2026-07-02

Abstract excerpt

<title>Abstract</title> <p>Zoonotic Sarbecoviruses present a documented threat to global health. Here, we report the recovery of an African clade-3 recombinant Sarbecovirus, PRD0038, and derivatives encoding reporter genes. Cryo-EM structural analyses of rPRD0038 revealed spike glycoprotein sites that facilitate the receptor-binding domain (RBD)-up conformation, enhancing replication in R. affinis but not human A...

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Literature Corpus work: 56e3a777-478d-508e-bea6-f7bd819c50b9
DOI: 10.21203/rs.3.rs-9954172/v1

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