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ACE2 binding is an ancestral and evolvable trait of sarbecoviruses

3 Feb 2022

Abstract excerpt

Abstract Two different sarbecoviruses have caused major human outbreaks in the past two decades 1,2 . Both of these sarbecoviruses, SARS-CoV-1 and SARS-CoV-2, engage ACE2 through the spike receptor-binding domain 2–6 . However, binding to ACE2 orthologues of humans, bats and other species has been observed only sporadically among the broader diversity of bat sarbecoviruses 7–11 . Here we use high-throughput...

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PMID: 35114688
DOI: 10.1038/s41586-022-04464-z

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