Article

Functional and Structural Basis of Omicron BA.3.2.1 Spike

2026-02-03

Abstract excerpt

SARS-CoV-2 Omicron descendant BA.3.2, derived from BA.3 and carrying 39 additional spike substitutions, prompts concerns about altered fitness and antigenicity. Using BA.3.2.1 as a representative sublineage, we have engineered live-attenuated mNeonGreen SARS-CoV-2 encoding spikes from BA.3.2.1 and the JN.1-derived LP.8.1 and XEC, and benchmarked them against BA.3 and KP.3 in Calu-3 cells and primary human airway e...

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Literature Corpus work: a6266303-89b5-5702-8111-d3ab9f0e82b5
DOI: 10.64898/2026.02.02.702852

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