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Article

Beyond the Pump: Unravelling Immunometabolic Crosstalk and Organelle Dynamics in Sepsis-Induced Cardiomyopathy.

Journal of cardiovascular translational research - 4 Aug 2026

Liu Guangfu, Hao Liya, Zhang Junfeng, Guo Yidan, Lv Guangyue, Liu Jiuyuan, Cheng Cheng, Yi Han, Zhou Jingjing, Liu Zhenzhu

Abstract excerpt

Sepsis-induced cardiomyopathy (SICM) has traditionally been viewed as pump-centered contractile failure, but this paradigm fails to explain the clinical spectrum and recovery patterns. This review presents an integrative framework where immunometabolic crosstalk and organelle dysfunction drive disease, including metabolic routing defects, mitochondrial fission, ER stress, and epigenetic regulation via m6A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42550336
DOI: 10.1007/s12265-026-10826-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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