Article

Human inborn errors of long-chain fatty acid oxidation show impaired inflammatory responses to TLR4-ligand LPS

2023-09-01

Abstract excerpt

<h4>ABSTRACT</h4> Stimulation of mammalian cells with inflammatory inducers such as lipopolysaccharide (LPS) leads to alterations in the activity of central cellular metabolic pathways. Interestingly, these metabolic changes seem to be important for the subsequent release of pro-inflammatory cytokines. This has become particularly clear for enzymes of the tricarboxylic acid (TCA) cycle such as succinate dehydroge...

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Literature Corpus work: 33809a4c-fbd0-5b45-9f2d-afd7967ae562
DOI: 10.1101/2023.08.30.555512

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