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p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb

30 Sept 2024

Abstract excerpt

Fibrosis and accumulation of senescent cells are common tissue changes associated with aging. Here, we show that the CDK inhibitor p21 (CDKN1A), known to regulate the cell cycle and the viability of senescent cells, also controls the expression of extracellular matrix (ECM) components in senescent and proliferating cells of the fibrotic lung, in a manner dependent on CDK4 and Rb phosphorylation. p21 knockout...

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PMID: 39349844
DOI: 10.1038/s44318-024-00246-7

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