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Article

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.

Science (New York, N.Y.) - 25 Sept 2015

Kang Chanhee, Xu Qikai, Martin Timothy D, Li Mamie Z, Demaria Marco, Aron Liviu, Lu Tao, Yankner Bruce A, Campisi Judith, Elledge Stephen J

Abstract excerpt

Cellular senescence is a terminal stress-activated program controlled by the p53 and p16(INK4a) tumor suppressor proteins. A striking feature of senescence is the senescence-associated secretory phenotype (SASP), a pro-inflammatory response linked to tumor promotion and aging. We have identified the transcription factor GATA4 as a senescence and SASP regulator. GATA4 is stabilized in cells undergoing senescence...

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Source

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Identifiers

PMID: 26404840
DOI: 10.1126/science.aaa5612
PMCID: PMC4942138

Genes

GATA4
ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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