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Article

Alpha-synuclein abundance and localization are regulated by the RNA-binding protein PUMILIO1

1 Aug 2025

Abstract excerpt

The protein α-synuclein, encoded by SNCA, accumulates in Parkinson's disease (PD) and other synucleinopathies for reasons that remain unclear. Here, we investigated whether SNCA is regulated in vivo by the RNA-binding protein PUM1. We establish that PUM1 binds to SNCA's 3' UTR in mouse and human cells. In induced neurons from patients with SNCA locus triplication, PUM1 mRNA levels are lower than in healthy...

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PMID: 40815569
DOI: 10.1016/j.celrep.2025.116145

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