Article

Uncovering Hidden Cancer Self-Dependencies through Analysis of shRNA-Level Dependency Scores

2023-03-24

Abstract excerpt

Large-scale short hairpin RNA (shRNA) screens on well-characterized human cancer cell lines have been widely used to identify novel cancer dependencies. However, the off-target effects of shRNA reagents pose a significant challenge in the analysis of these screens. To mitigate these off-target effects, various approaches have been proposed that aggregate different shRNA viability scores targeting a gene into a sin...

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Literature Corpus work: 3dc9cab4-e854-5e32-b17a-9a070ee56d0b
DOI: 10.1101/2023.03.23.533901

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