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Article

Genetic proxies for PCSK9 inhibition associate with lipoprotein(a): Effects on coronary artery disease and ischemic stroke

26 Sept 2022

Abstract excerpt

BACKGROUND AND AIMS: Post hoc analyses of clinical trials show that PCSK9 inhibitors might lower lipoprotein(a), but whether this effect contributes to reductions in cardiovascular risk remains unknown. We aimed to assess whether genetically proxied PCSK9 inhibition influences lipoprotein(a) (Lp(a)), and whether any such effect could mediate its effects on coronary artery disease (CAD) and ischemic stroke (IS)....

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PMID: 36244797
DOI: 10.1016/j.atherosclerosis.2022.09.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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