Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring Internal Ribosome Entry Sites as Therapeutic Targets

20 Oct 2015

Abstract excerpt

Initiation of eukaryotic mRNA translation may proceed via several different routes, each requiring a different subset of factors and relying on different and specific interactions between the mRNA and the ribosome. Two modes predominate: (i) so-called cap-dependent initiation, which requires all canonical initiation factors and is responsible for about 95-97% of all initiation events in eukaryotic cells; and (ii)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA and protein synthesis mechanisms
Share to RNA Research and Splicing
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26539410
DOI: 10.3389/fonc.2015.00233

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring Internal Ribosome Entry Sites as Therapeutic TargetsPMID 26539410Read ↗

Cellular IRES-mediated translationSemantic proximity Read ↗

The hepatitis C virus internal ribosome-entry site: a new target for antiviral researchSemantic proximity Read ↗

IRES Trans-Acting Factors, Key Actors of the Stress ResponseSemantic proximity Read ↗

IRES Trans-Acting Factors, Key Actors of the Stress ResponseSemantic proximity Read ↗

Internal Ribosome Entry Site (IRES)-Mediated Translation and Its Potential for Novel mRNA-Based Therapy DevelopmentSemantic proximity Read ↗

The role of IRES <i>trans</i>-acting factors in regulating translation initiationSemantic proximity Read ↗

Cap- and IRES-Independent Scanning Mechanism of Translation Initiation as an Alternative to the Concept of Cellular IRESsSemantic proximity Read ↗

Understanding the potential of hepatitis C virus internal ribosome entry site domains to modulate translation initiation via their structure and functionSemantic proximity Read ↗

Translation initiation by factor-independent binding of eukaryotic ribosomes to internal ribosomal entry sitesSemantic proximity Read ↗

Functional Characterization of the Internal Ribosome Entry Site of eIF4G mRNASemantic proximity Read ↗

Translational Control of COVID-19 and Its Therapeutic ImplicationSemantic proximity Read ↗

Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodelingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.