Article

Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein mediated neurodegeneration

2022-07-24

Abstract excerpt

<h4>ABSTRACT</h4> Heterozygous variants in the glucocerebrosidase ( GBA ) gene are common and potent risk factors for Parkinson’s disease (PD). GBA also causes the autosomal recessive lysosomal storage disorder (LSD), Gaucher disease, and emerging evidence from human genetics implicates many other LSD genes in PD susceptibility. We have systemically tested 88 conserved fly homologs of 38 human LSD genes for re...

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Literature Corpus work: fd9b9bfb-d8d7-544e-a9ca-e84ce2c0710e
DOI: 10.1101/2022.07.23.501240

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