Article

Delineating effect of cationic head group and preparation method on transfection versus toxicity of lipid-based nanoparticles for gene delivery

2023-03-29

Abstract excerpt

<title>Abstract</title> Gene therapy using plasmid DNA (pDNA) is well-explored for variety of genetic diseases. However, its susceptibility to enzymatic degradation desires an optimal delivery system for efficient cellular uptake, transfection, and stability <italic>in vivo</italic>. Non-viral vectors like lipoplexes and LNPs have gained traction but there is no comparative evaluation of these lipid nanocarrie...

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Literature Corpus work: e07fcfe0-3f86-52c8-bbb2-87be3b0534a6
DOI: 10.21203/rs.3.rs-2649244/v1

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