Article

Revealing a Correlation between Structure and <i>in vitro</i> Activity of mRNA Lipid Nanoparticles

2024-09-02

Abstract excerpt

<h4>ABSTRACT</h4> mRNA-loaded lipid nanoparticles (mRNA-LNPs) represent a promising platform for disease prevention, cancer immunotherapy, and gene editing, etc. Despite the success of mRNA-LNPs based vaccines, the relationship between their structure and efficacy remains elusive. Here, we generated a series of mRNA-LNPs with varied structural properties and in vitro cellular activities by altering their process...

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Literature Corpus work: 285aad4e-e5a3-5c9d-9b8b-72319888b65f
DOI: 10.1101/2024.09.01.610730

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