Article

Enhancing Cytoplasmic Expression of Exogenous mRNA through Dynamic Mechanical Stimulation

2024-06-22

Abstract excerpt

Ionizable lipid nanoparticles (LNPs) have been pivotal in combating COVID-19, and numerous preclinical and clinical studies have highlighted their potential in nucleic acid-based therapies and vaccines. However, the effectiveness of endosomal escape for the nucleic acid cargos encapsulated in LNPs is still low, leading to suboptimal treatment outcomes and side effects. Hence, improving endosomal escape is crucial...

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Literature Corpus work: 53f8ba1b-6214-58d2-9743-d83116f91824
DOI: 10.1101/2024.06.19.599708

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