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Article

Exposure accumulation drives age-dependent disease architectures and polygenic risk scores

2025-09-02

Abstract excerpt

Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to separate age-dependent genetic and environmental variance across complex traits and diseases. When applying our approach to 16 UK Biobank quantitative traits (average N=180K), we found environmental variance accumulates with age, leading to decreasing heritabi...

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Identifiers and source

Literature Corpus work
2a424e33-31eb-57bd-a857-a94786b62368
DOI
10.1101/2025.08.29.25334745
Open publication

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Exposure accumulation drives age-dependent disease architectures and polygenic risk scoresDOI 10.1101/2025.08.29.25334745
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