Back to search

Article

Proinflammatory cytokines mediate pancreatic β-cell specific alterations to Golgi morphology via iNOS-dependent mitochondrial inhibition

2025-01-29

Abstract excerpt

<h4>Summary</h4> Type 1 diabetes (T1D) is caused by the selective autoimmune ablation of pancreatic β-cells. Emerging evidence reveals β-cell secretory dysfunction arises early in T1D development and may contribute to diseases etiology; however, the underlying mechanisms are not well understood. Our data reveal that proinflammatory cytokines elicit a complex change in the β-cell’s Golgi structure and function. Th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3d6dab91-3d37-5062-b5af-805e4e90e29e
DOI
10.1101/2025.01.29.635550
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Proinflammatory cytokines mediate pancreatic β-cell specific alterations to Golgi morphology via iNOS-dependent mitochondrial inhibitionDOI 10.1101/2025.01.29.635550
Split but merge: Golgi fragmentation in physiological and pathological conditionsSemantic proximity
Inside the β Cell: Molecular Stress Response Pathways in Diabetes PathogenesisSemantic proximity
Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesisSemantic proximity
Inflammatory signaling pathways in pancreatic β-cell: New insights into type 2 diabetes pathogenesisSemantic proximity
An accomplice more than a mere victim: The impact of β-cell ER stress on type 1 diabetes pathogenesisSemantic proximity
The Golgi Apparatus: A Voyage through Time, Structure, Function and Implication in Neurodegenerative DisordersSemantic proximity
Islet inflammation in type 2 diabetes and physiologySemantic proximity
Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesisSemantic proximity
Beta-Cell Pyroptosis – A Burning Flame in Type 1 Diabetes?Semantic proximity
Islet inflammation in human type 1 diabetes mellitusSemantic proximity
Interactions between islet-resident macrophages and β cells in diabetesSemantic proximity
Mitochondrial and protein homeostasis pathways are transcriptionally impaired in islets during type 1 diabetes pathogenesisSemantic proximity
Select a neighboring publication to make it the new centre.