Back to search

Article

Beta-Cell Pyroptosis – A Burning Flame in Type 1 Diabetes?

2024-01-08

Abstract excerpt

Immune-mediated destruction of the beta-cells in the pancreatic islets of Langerhans is the underlying cause of type 1 diabetes (T1D). Despite decades of research, the exact mechanisms involved at the beta-cell level during the development of disease remain poorly understood. This includes the mode(s) of beta-cell death and signaling events implicated in exacerbating local islet inflammation and immune cell infilt...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b5ec9796-14f9-51cb-af00-0b28a098fa37
DOI
10.1101/2024.01.05.574294
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Beta-Cell Pyroptosis – A Burning Flame in Type 1 Diabetes?DOI 10.1101/2024.01.05.574294
Life and death of β cells in Type 1 diabetes: A comprehensive review.Semantic proximity
Death effectors of β-cell apoptosis in type 1 diabetesSemantic proximity
Inflammatory signaling pathways in pancreatic β-cell: New insights into type 2 diabetes pathogenesisSemantic proximity
Apoptosis in the pathophysiology of diabetes mellitus.Semantic proximity
β-Cell death during progression to diabetesSemantic proximity
Islet inflammation in human type 1 diabetes mellitusSemantic proximity
The role of pyroptosis in inflammatory diseasesSemantic proximity
Pancreas Β-Cells in Type 1 and Type 2 Diabetes: Cell Death, Oxidative Stress and Immune Regulation. Recently Appearing Changes in Diabetes ConsequencesSemantic proximity
Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?Semantic proximity
Oxidative and nitrosative stress in β-cell apoptosis: their contribution to β-cell lossin type 1 diabetes mellitusSemantic proximity
Evidence of Contribution of iPLA2β-Mediated Events During Islet β-Cell Apoptosis Due to Proinflammatory Cytokines Suggests a Role for iPLA2β in T1D DevelopmentSemantic proximity
Role of pyroptosis in diabetic cardiomyopathy: an updated reviewSemantic proximity
Select a neighboring publication to make it the new centre.