Article

FGF19 and its analog Aldafermin cooperate with MYC to induce aggressive hepatocarcinogenesis

2023-09-17

Abstract excerpt

FGF19 hormone has pleiotropic metabolic functions, notably the modulation of insulin sensitivity, glucose/lipid metabolism and energy homeostasis. On top of its physiological metabolic role, FGF19 has been identified as a potentially targetable oncogenic driver, notably in hepatocellular carcinoma (HCC). Nevertheless, FGF19 remained an attractive candidate for treatment of metabolic disease, prompting the developm...

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Literature Corpus work: 3d6a4765-420f-5d9b-beaa-372ad36fcdd6
DOI: 10.1101/2023.09.15.557921

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