Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production.

Breast cancer research : BCR - 7 Feb 2017

Ter Braak Bas, Siezen Christine L, Lee Joo S, Rao Pooja, Voorhoeve Charlotte, Ruppin Eytan, van der Laan Jan Willem, van de Water Bob

Abstract excerpt

BACKGROUND: The insulin-like growth factor 1 (IGF1) signaling axis plays a major role in tumorigenesis. In a previous experiment, we chronically treated mice with several agonists of the IGF1 receptor (IGF1R). We found that chronic treatment with insulin analogues with high affinity towards the IGF1R (IGF1 and X10) decreased the mammary gland tumor latency time in a p53R270H/+WAPCre mouse model. Frequent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enhancer of Zeste Homolog 2 Protein
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose

Share to Glycolysis

Share to Insulin-Like Growth Factor I

Share to ras Proteins

Share to Receptor, IGF Type 1

Share to Tumor Burden

Source

Open in PubMed Open full text

Identifiers

PMID: 28173837
DOI: 10.1186/s13058-017-0802-0
PMCID: PMC5297135

Genes

IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production.PMID 28173837Read ↗

Igf1r as a therapeutic target in a mouse model of basal-like breast cancerSemantic proximity Read ↗

Targeting the Insulin-like Growth Factor Receptor: Developing Biomarkers from Gene Expression ProfilingSemantic proximity Read ↗

IGF1R Inhibition in Mammary Epithelia Promotes Canonical Wnt Signaling and Wnt1-Driven TumorsSemantic proximity Read ↗

Insulin Receptor Isoforms and Insulin Growth Factor-like Receptors: Implications in Cell Signaling, Carcinogenesis, and ChemoresistanceSemantic proximity Read ↗

Hallmarks of cancer: The insulin-like growth factors perspectiveSemantic proximity Read ↗

Impact of constitutive IGF1/IGF2 stimulation on the transcriptional program of human breast cancer cellsSemantic proximity Read ↗

LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancerSemantic proximity Read ↗

Oncogene activation induces metabolic transformation resulting in insulin-independence in human breast cancer cells.Semantic proximity Read ↗

Insulin-Like Growth Factor-I Activates Gene Transcription Programs Strongly Associated With Poor Breast Cancer PrognosisSemantic proximity Read ↗

Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapySemantic proximity Read ↗

PIK3CA gain-of-function mutation in adipose tissue induces metabolic reprogramming with Warburg-like effect and severe endocrine disruption.Semantic proximity Read ↗

A Precision Medicine Approach to Metabolic Therapy for Breast Cancer in MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.