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Article

Monomeric/dimeric forms of Fgf15/FGF19 show differential activity in hepatocyte proliferation and metabolic function.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2021

Williams Courtney M, Harper Calderon Jessica, E Hock, Jimenez Yasalp, Barringer Kevin, Carbonaro Marisa, Molina-Portela Maria Del Pilar, Thurston Gavin, Li Zhe, Daly Christopher

Abstract excerpt

Human Fibroblast Growth Factor 19 (FGF19) and mouse ortholog Fgf15 play similar roles in liver regeneration and metabolism via the activation of Fgfr4/b-klotho (Klb). Monomeric FGF19 and dimeric Fgf15 are both necessary for liver regeneration and proper bile acid (BA) metabolism. FGF19 elicits stronger effects than Fgf15 on glucose and fatty acid metabolism and only FGF19 induces hepatocellular carcinoma (HCC)....

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PMID: 33484478
DOI: 10.1096/fj.202002203R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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