Article
Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19).
Proceedings of the National Academy of Sciences of the United States of America - 10 Aug 2010
Wu Xinle, Ge Hongfei, Lemon Bryan, Vonderfecht Steven, Baribault Helene, Weiszmann Jennifer, Gupte Jamila, Gardner Jonitha, Lindberg Richard, Wang Zhulun, Li Yang
Abstract excerpt
FGF19 and FGF21 are distinctive members of the FGF family that function as endocrine hormones. Their potent effects on normalizing glucose, lipid, and energy homeostasis in disease models have made them an interesting focus of research for combating the growing epidemics of diabetes and obesity. Despite overlapping functions, FGF19 and FGF21 have many discrete effects, the most important being that FGF19 has both...
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