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Article

A nontumorigenic variant of FGF19 treats cholestatic liver diseases.

Science translational medicine - 30 Jul 2014

Luo Jian, Ko Brian, Elliott Michael, Zhou Mei, Lindhout Darrin A, Phung Van, To Carmen, Learned R Marc, Tian Hui, DePaoli Alex M, Ling Lei

Abstract excerpt

Hepatic accumulation of bile acids is central to the pathogenesis of cholestatic liver diseases. Endocrine hormone fibroblast growth factor 19 (FGF19) may reduce hepatic bile acid levels through modulation of bile acid synthesis and prevent subsequent liver damage. However, FGF19 has also been implicated in hepatocellular carcinogenesis, and consequently, the potential risk from prolonged exposure to...

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Source

Identifiers

PMID: 25080475
DOI: 10.1126/scitranslmed.3009098

Genes

FGF19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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