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Article

Regulation of amphiregulin gene expression by β-catenin signaling in human hepatocellular carcinoma cells: a novel crosstalk between FGF19 and the EGFR system.

PloS one - 1 Jan 2012

Latasa Maria U, Salis Fabiana, Urtasun Raquel, Garcia-Irigoyen Oihane, Elizalde Maria, Uriarte Iker, Santamaria Monica, Feo Francesco, Pascale Rosa M, Prieto Jesús, Berasain Carmen, Avila Matías A

Abstract excerpt

Hepatocellular carcinoma (HCC) is the most prevalent liver tumor and a deadly disease with limited therapeutic options. Dysregulation of cell signaling pathways is a common denominator in tumorigenesis, including hepatocarcinogenesis. The epidermal growth factor receptor (EGFR) signaling system is commonly activated in HCC, and is currently being evaluated as a therapeutic target in combination therapies. We and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23285165
DOI: 10.1371/journal.pone.0052711
PMCID: PMC3527604

Genes

EGFR
FGF19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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