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Article

Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening.

Cancer cell - 8 Mar 2011

Sawey Eric T, Chanrion Maia, Cai Chunlin, Wu Guanming, Zhang Jianping, Zender Lars, Zhao Alice, Busuttil Ronald W, Yee Herman, Stein Lincoln, French Dorothy M, Finn Richard S, Lowe Scott W, Powers Scott

Abstract excerpt

We screened 124 genes that are amplified in human hepatocellular carcinoma (HCC) using a mouse hepatoblast model and identified 18 tumor-promoting genes, including CCND1 and its neighbor on 11q13.3, FGF19. Although it is widely assumed that CCND1 is the main driving oncogene of this common amplicon (15% frequency in HCC), both forward-transformation assays and RNAi-mediated inhibition in human HCC cells...

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Source

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Identifiers

PMID: 21397858
DOI: 10.1016/j.ccr.2011.01.040
PMCID: PMC3061399

Genes

FGF19
CCND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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