Article
The potential of mitochondrial genome engineering.
Nature reviews. Genetics - 1 Apr 2022
Silva-Pinheiro Pedro, Minczuk Michal
Abstract excerpt
Mitochondria are subject to unique genetic control by both nuclear DNA and their own genome, mitochondrial DNA (mtDNA), of which each mitochondrion contains multiple copies. In humans, mutations in mtDNA can lead to devastating, heritable, multi-system diseases that display different tissue-specific presentation at any stage of life. Despite rapid advances in nuclear genome engineering, for years, mammalian mtDNA...
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