Article
Manipulating and elucidating mitochondrial gene expression with engineered proteins.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 20 Jan 2020
Wallis Christopher P, Scott Louis H, Filipovska Aleksandra, Rackham Oliver
Abstract excerpt
Many conventional, modern genome engineering tools cannot be used to study mitochondrial genetics due to the unusual structure and physiology of the mitochondrial genome. Here, we review a number of newly developed, synthetic biology-based approaches for altering levels of mutant mammalian mitochondrial DNA and mitochondrial RNAs, including transcription activator-like effector nucleases, zinc finger nucleases...
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