Therapeutic Manipulation of mtDNA Heteroplasmy: A Shifting Perspective.

Abstract excerpt

Mutations of mitochondrial DNA (mtDNA) often underlie mitochondrial disease, one of the most common inherited metabolic disorders. Since the sequencing of the human mitochondrial genome and the discovery of pathogenic mutations in mtDNA more than 30 years ago, a movement towards generating methods for robust manipulation of mtDNA has ensued, although with relatively few advances and some controversy. While...

Topics

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• DNA, Mitochondrial
• Heteroplasmy
• Mitochondria
• Mitochondrial Diseases
• Mutation