Article

DAPEG-Modified Analogs of Human Cathelicidin LL-37: Enhanced Proteolytic Stability and Selective Modulation of Neutrophil Degranulation

2026-06-01

Abstract excerpt

The human cathelicidin LL-37 (37 amino acids; net charge +6) combines broad-spectrum antimicrobial activity with extensive immunomodulatory function, but its therapeutic exploitation is limited by rapid proteolytic degradation and post-translational inactivation through PAD-mediated citrullination of its arginine residues. We synthesized six analogs of LL-37 in which all five arginine residues (positions 7, 19, 23...

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Literature Corpus work: 130e4345-70ee-5de0-a9db-ffbc2e7a6dab
DOI: 10.20944/preprints202606.0060.v1

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