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Article

Systematic alanine and stapling mutational analysis of antimicrobial peptide Chem-KVL.

Bioorganic & medicinal chemistry letters - 15 Jul 2024

Zhen Borui, Geng Chenchen, Yang Yi, Liang Haiyan, Jiang Yunyun, Li Xiang, Ye Guangming

Abstract excerpt

Chem-KVL is a tandem repeating peptide, with 14 amino acids that was modified based on a short peptide from a fragment of the human host defense protein chemerin. Chem-KVL increases cationicity and hydrophobicity and shows broad-spectrum antibacterial activity. To determine the molecular determinants of Chem-KVL and whether staple-modified Chem-KVL would improve antibacterial activity and protease stability or...

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Identifiers

PMID: 38735344
DOI: 10.1016/j.bmcl.2024.129794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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