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Hybrid Derivative of Cathelicidin and Human Beta Defensin-2 Against Gram-Positive Bacteria: A Novel Approach for the Treatment of Bacterial Keratitis

2021-04-22

Abstract excerpt

<h4>ABSTRACT</h4> Bacterial keratitis (BK) is a major cause of corneal blindness globally. This study aimed to develop a novel class of antimicrobial therapy, based on human-derived hybrid host defense peptides (HyHDPs), for treating BK. HyHDPs were rationally designed through combination of functional amino acids in parent HDPs, including LL-37 and human beta-defensin (HBD)-1 to −3. Minimal inhibitory concentrat...

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Literature Corpus work
97fd4e7b-b767-5736-9679-ea1f168b90c5
DOI
10.1101/2021.04.22.440925
Open publication

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Hybrid Derivative of Cathelicidin and Human Beta Defensin-2 Against Gram-Positive Bacteria: A Novel Approach for the Treatment of Bacterial KeratitisDOI 10.1101/2021.04.22.440925
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