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Multiple System Atrophy: Pathology, Pathogenesis, and Path Forward

15 Oct 2024

Abstract excerpt

Multiple system atrophy (MSA) is a fatal neurodegenerative disease characterized by autonomic failure and motor impairment. The hallmark pathologic finding in MSA is widespread oligodendroglial cytoplasmic inclusions rich in aggregated α-synuclein (αSyn). MSA is widely held to be an oligodendroglial synucleinopathy, and we outline lines of evidence to support this assertion, including the presence of early myelin...

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PMID: 39405585
DOI: 10.1146/annurev-pathmechdis-051122-104528

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