Article

RM1mAb avoids Intracellular degradation to Synergistically inhibit NLRP3 Inflammasome Activation in Familial Cold Autoinflammatory Syndrome

2025-12-12

Abstract excerpt

The NLRP3 inflammasome enables release of mitochondrial DNA to circulation. Circulating oxidized mitochondrial DNA generated in response to NLRP3 inflammasome activation functions as an alarmin that contributes to the maintenance of systemic inflammation. The discovery that NLRP3 could cleave oxidized mtDNA led to repurposed chemical inhibitors that dually target NLRP3 and DNA glycosylase OGG1, resulting in pro-su...

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Literature Corpus work: 3d2dddc1-ddb0-51c1-a7c9-bc4f2fe25767
DOI: 10.64898/2025.12.09.693294

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