Article
The human disease-associated gene ZNFX1 controls inflammation through inhibition of the NLRP3 inflammasome.
The EMBO journal - 1 Nov 2024
Huang Jing, Wang Yao, Jia Xin, Zhao Changfeng, Zhang Meiqi, Bao Mi, Fu Pan, Cheng Cuiqin, Shi Ruona, Zhang Xiaofei, Cui Jun, Wan Gang, Xu Anlong
Abstract excerpt
Inherited deficiency of zinc finger NFX1-type containing 1 (ZNFX1), a dsRNA virus sensor, is associated with severe familial immunodeficiency, multisystem inflammatory disease, increased susceptibility to viruses, and early mortality. However, limited treatments for patients with pathological variants of ZNFX1 exist due to an incomplete understanding of the diseases resulting from ZNFX1 mutations. Here, we...
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