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Article

Computational Modeling of NLRP3 Identifies Enhanced ATP Binding and Multimerization in Cryopyrin-Associated Periodic Syndromes.

Frontiers in immunology - 1 Jan 2020

Samson Jenny Mae, Ravindran Menon Dinoop, Vaddi Prasanna K, Kalani Williams Nazanin, Domenico Joanne, Zhai Zili, Backos Donald S, Fujita Mayumi

Abstract excerpt

Cyropyrin-associated periodic syndromes (CAPS) are clinically distinct syndromes that encompass a phenotypic spectrum yet are caused by alterations in the same gene, NLRP3. Many CAPS cases and other NLRP3-autoinflammatory diseases (NLRP3-AIDs) are directly attributed to protein-coding alterations in NLRP3 and the subsequent dysregulation of the NLRP3 inflammasome leading to IL-1β-mediated inflammatory states....

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Source

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Identifiers

PMID: 33329557
DOI: 10.3389/fimmu.2020.584364
PMCID: PMC7711157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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