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Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement

16 Feb 2018

Abstract excerpt

Recognizing danger signals In the classical complement pathway, the C1 initiation complex binds to danger patterns on the surface of microbes or damaged host cells and triggers an immune response. Immunoglobulin G (IgG) antibodies form hexamers on cell surfaces that have high avidity for the C1 complex. Ugurlar et al. used cryo–electron microscopy to show how a hexamer of C1 complexes interacts with the IgG...

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PMID: 29449492
DOI: 10.1126/science.aao4988

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