Article

Computational Druggability Assessment of Mitochondrial Targets: Structure-Function Constraints and Binding Site Characterization

2026-04-07

Abstract excerpt

<title>Abstract</title> <p>Background Precision drug design for mitochondrial disease requires a systematic evaluation of whether each drug target possesses a pharmacologically tractable binding site. Druggability is determined by the intersection of structural accessibility, ligand efficiency evidence, pharmacological precedent, and mitochondrial delivery feasibility. No comprehensive druggability map exists fo...

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Literature Corpus work: 3d2400ee-90ae-5b8b-b738-b53cdb9dab20
DOI: 10.21203/rs.3.rs-9305508/v1

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