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Targeting Dual-Impact FBXO7 Mutants Implicated in Parkinson’s Disease and Cancer: An Integrated Approach Using Density Functional Theory, Molecular Docking, and Molecular Dynamics

2025-10-15

Abstract excerpt

<title>Abstract</title> <p>Cancer and Parkinson's disease (PD), despite their distinct pathologies, exhibit shared molecular mechanisms, particularly involving the dysregulation of autophagy and the ubiquitin-proteasome system. FBXO7 emerges as a crucial protein at the intersection of these diseases, possessing a subset of five mutations with roles in both neurodegeneration and oncogenesis. This study investigate...

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Literature Corpus work: baa40e7b-c5ef-5584-9af2-bd2f63126fe5
DOI: 10.21203/rs.3.rs-7673889/v1

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