Article

Interpretable tissue-resolved drug toxicity prediction with pathway-level mechanism attribution

2026-07-17

Abstract excerpt

<title>Abstract</title> <p>Drug-induced adverse effects often depend on tissue context, yet most computational toxicity models return endpoint-specific scores without mechanisms. We developed ToxiPred, a two-tower neural network that predicts a toxicity-oriented drug sensitivity for each drug-tissue pair. ToxiPred combines chemical structure, target annotations and measured or imputed perturbation profiles with t...

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Literature Corpus work: ebd9a1ea-2eae-52f9-8e6c-a1ebda60b10b
DOI: 10.21203/rs.3.rs-9996365/v1

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