Article

AI platform for CRISPR functional mapping and function-based drug design

2026-05-11

Abstract excerpt

Conventional structure-based drug design has high clinical failure rates due to the disconnect where binding affinity does not guarantee safe functional modulation. To bridge this gap, we present CRISPRtile, a cloud-based platform for function-based drug design. By deriving library coverage optimization equations and leveraging AI to correct CRISPR guide biases, we generated toxicity and functional landscapes with...

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Identifiers and source

Literature Corpus work: c52506de-7b85-5766-addd-25999eb4f1c0
DOI: 10.64898/2026.05.06.722817

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