Bridging the gap between target-based and phenotypic-based drug discovery.

Abstract excerpt

INTRODUCTION: The unparalleled progress in science of the last decades has brought a better understanding of the molecular mechanisms of diseases. This promoted drug discovery processes based on a target approach. However, despite the high promises associated, a critical decrease in the number of first-in-class drugs has been observed. AREAS COVERED: This review analyses the challenges, advances, and...

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