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Article

Phenotypic adaptations of Leishmania donovani to recurrent miltefosine exposure and impact on sand fly infection.

Parasites & vectors - 22 Feb 2020

Hendrickx Sarah, Van Bockstal Lieselotte, Bulté Dimitri, Mondelaers Annelies, Aslan Hamide, Rivas Luis, Maes Louis, Caljon Guy

Abstract excerpt

BACKGROUND: Since the introduction of miltefosine (MIL) as first-line therapy in the kala-azar elimination programme in the Indian subcontinent, treatment failure rates have been increasing. Since parasite infectivity and virulence may become altered upon treatment relapse, this laboratory study assessed the phenotypic effects of repeated in vitro and in vivo MIL exposure. METHODS: Syngeneic Leishmania donovani...

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Identifiers

PMID: 32087758
DOI: 10.1186/s13071-020-3972-z
PMCID: PMC7036194

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