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A Second Generation Leishmanization Vaccine with a Markerless Attenuated <i>Leishmania major</i> Strain using CRISPR gene editing

2020-05-05

Abstract excerpt

Leishmaniasis is a debilitating and often fatal neglected tropical disease caused by Leishmania protozoa transmitted by infected sand flies. Vaccination through leishmanization with live Leishmania major has been used successfully but is no longer practiced because it resulted in unacceptable skin lesions. A second generation leishmanization is described here using a CRISPR genome edited L. major strain ( LmCe...

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Identifiers and source

Literature Corpus work
24e88eba-ae0a-5bc0-8a83-fb7de06dc89e
DOI
10.1101/2020.05.04.077115
Open publication

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A Second Generation Leishmanization Vaccine with a Markerless Attenuated <i>Leishmania major</i> Strain using CRISPR gene editingDOI 10.1101/2020.05.04.077115
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