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Article

Miltefosine Resistant Field Isolate From Indian Kala-Azar Patient Shows Similar Phenotype in Experimental Infection.

Scientific reports - 4 Sept 2017

Khanra Supriya, Sarraf Nibedeeta R, Das Anjan K, Roy Syamal, Manna Madhumita

Abstract excerpt

Emergence of resistance to drugs used to treat the Indian Kala-azar patients makes control strategy shattered. In this bleak situation, Miltefosine (MIL) was introduced to treat mainly antimonial unresponsive cases. Within years, resistance to MIL has been reported. While checking the MIL sensitivity of the recent KA clinical isolates (n = 26), we came across one isolate which showed four times more EC50 for MIL...

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Identifiers

PMID: 28871097
DOI: 10.1038/s41598-017-09720-1
PMCID: PMC5583325

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